EFFECT OF BEVACIZUMAB ON α-SMOOTH MUSCLE ACTIN EXPRESSION AND FIBROBLAST COUNT IN TRABECULECTOMY AREA TOWARDS PREVENTION OF FIBROSIS

Objective to analyze the effect of bevacizumab on α-smooth muscle actin expression and fibroblast count in trabeculectomy area rabbit models order find a safer modulator wound healing improve surgical outcome. Material methods 16 New Zealand white rabbits aged 4-6 months weigh between 2,5-3,5 kg were performed their right eyes with postoperative subconjunctival injection BSS Bevacizumab. Rabbits put into control group using simple random sampling. Examination done day 1, 7, 14 subjects terminated enucleation 14. The samples histologically stained Haematoxyline-Eosin immunohistochemistry antibody differ myofibroblast from α-SMA collected immunoreactive score. Result Mann Whitney u test independent t-test used data, we found both less compared which indicates myofibroblast, fibroblast, scarring potential area. Conclusion inhibits proliferation its differentiation that lead collagen production fibrosis.